DEVELOPMENT AND IN VITRO EVALUATION OF PHYTOSOMES OF ELLAGIC ACID

Objectives: The main objective of the present work is to enhance bioavailability ellagic acid (EA) by increasing its dissolution there allowing for exploitation therapeutic effects. Methods: Phytosomes containing EA were prepared anti-solvent precipitation method. phytosomes evaluated drug entrapment efficiency, in vitro release, and excipient interaction studies. Results: Formulation F2 soya lecithin ratio (1:2) showed highest percentage release as 85.40% 60 min 95.86% 120 min. efficiency values satisfactory. There no interactions between excipients used preparation according Fourier-transform infrared spectra pure phytosomes. Conclusion: successfully produced method was satisfactory almost all formulations. exhibited percent possess optimum bioavailability.